This webinar can be centered on lyophilized formulations of organic molecules (eg, proteins). This presentation will study the primary steps within the lyophilization course of and the mechanisms by which excipients present stabilization to protein throughout freezing, drying, storage, and reconstitution.
Register Free: https://www.pharmtech.com/pt_w/biological-molecule-stabilization
Occasion Overview:
Within the first 10 minutes, Ascendia Prescription drugs will current its experience and capabilities in nanoparticle applied sciences. Within the following 40 minutes this webinar can be centered on lyophilized formulations of organic molecules (eg, proteins). This presentation will study the primary steps within the lyophilization course of and the mechanisms by which excipients present stabilization to protein throughout freezing, drying, storage, and reconstitution. The important thing bodily elements governing long-term stability additionally can be mentioned. Throughout freezing, efficient excipients (eg, sucrose or trehalose) stabilize proteins by the preferential exclusion mechanism. Throughout drying the stabilizer molecules change water molecules faraway from the floor of the protein (water substitute mechanism). Surfactants can stabilize the protein throughout freezing and reduce aggregation throughout reconstitution. For long-term storage stability, minimal standards embrace retention of native protein construction throughout freezing and drying; a formulation glass transition temperature effectively above the deliberate storage temperature; and comparatively low residual water content material (eg, 1%).
Key Studying Aims:
On this webinar you’ll be taught:
- Ascendia’s experience and capabilities
- The primary steps within the lyophilization course of and the way proteins behave throughout these steps
- The mechanisms for protein stabilization by excipients throughout freezing, drying, storage, and reconstitution
- The minimal bodily standards for assuring long-term stability of lyophilized protein formulations
Who Ought to Attend:
- Formulation scientists in business
- Analytical chemists in business
- College college students and professors
- Managers, VPs, chief scientific officers, pharma consultants, and regulatory scientists
Audio system:
Shaukat Ali, PhD
Senior Director of Scientific Affairs and Technical Advertising
Ascendia
Shaukat Ali, PhD, acquired his PhD diploma from the Metropolis College of New York in chemistry and carried out his postdoctoral work in bodily biochemistry on the College of Minnesota and Cornell College. His areas of experience embrace liposomes, lipid nanoparticles, amorphous stable dispersions, SEDDS, managed launch applied sciences, and movie applied sciences. He has revealed over 60 scientific and technical papers and holds a number of US and European patents. Dr Ali is a member of the editorial advisory boards of American Pharmaceutical Assessment, BioPharma Asia, and Contract Pharma, amongst different journals. Dr Ali is at present serving as a member of USP Excipients Check Strategies Skilled Committee (2020-2025). He’s the recipient of IPEC Basis’s Henk de Jong Trade Analysis Achievement in Excipient Know-how Award for his important contributions within the subject of excipient applied sciences. Dr Ali is an American Affiliation of Pharmaceutical Scientists fellow.
John Carpenter, PhD
John F. Carpenter, PhD, is a professor emeritus of pharmaceutical sciences on the College of Colorado Skaggs Faculty of Pharmacy and Pharmaceutical Sciences, and a cofounder and codirector of the College of Colorado Middle for Pharmaceutical Biotechnology. His analysis pursuits embrace mechanisms for protein degradation and stabilization in pharmaceutical formulations throughout bioprocessing and in drug-delivery methods. He has labored for a number of years to outline rational methods for stabilizing proteins and vaccines throughout freeze-drying and storage within the dried stable. He has revealed greater than 300 peer-reviewed papers and is an inventor on greater than 30 patents. He’s editor for opinions and commentaries for the Journal of Pharmaceutical Sciences. He serves on the editorial advisory boards for Pharmaceutical Analysis, The AAPS Journal, Journal of Pharmaceutical Sciences, Present Pharmaceutical Biotechnology, Molecular Pharmaceutics, and BioPharm Worldwide. He has acquired a number of educating awards and the Ebert Prize. He’s a fellow of the American Affiliation for Development of Science, the American Affiliation of Pharmaceutical Scientists (AAPS) and the Nationwide Academy of Inventors. He has acquired the AAPS Analysis Achievement Award in Biotechnology. He additionally was a cofounder and an organizer for the Colorado Protein Stability Convention.
Register Free: https://www.pharmtech.com/pt_w/biological-molecule-stabilization