The place is the lab?
We’re positioned in Lund, a small metropolis in Southern Sweden. The College was based in 1666, and consists of many elderly lovely buildings. The lab is affiliated with the Division of Pediatrics, and we’re a part of the Lund Stem Cell Heart.
Lab web site: Tissue Development and Evolution
Analysis abstract
We’re intrigued by how we are able to make the most of the setting of regular embryonic improvement to grasp tumor initiation. Our focus lies totally on how most cancers varieties neuroblastoma and paraganglioma develop throughout embryogenesis. These cancers come up within the adrenal gland and alongside (para)sympathetic ganglia, and originate from cells of the trunk neural crest stem cell inhabitants. Neuroblastoma is the commonest tumor kind in infants. It’s believed to come up on account of developmental defects throughout embryogenesis, however the exact origin and reason for initiation is unknown. Paragangliomas are then again grownup gradual rising tumors, but additionally these are believed to be primed throughout improvement of the neural crest. We primarily use human patient-derived cells and chick embryos to dissect the position of neural crest particular genes in most cancers initiation and development. We develop methods the place we are able to analyze full-scale organogenesis and tumor formation when it comes to the genomic, proteomic, and morphological panorama following genetic insults within the trunk neural crest stem cell inhabitants throughout embryonic improvement.
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Lab roll name
Sinan Karakaya is a postdoc, exploring the position of a dysregulated hypoxic response in each regular improvement and the development of tumors, particularly specializing in paraganglioma. His analysis investigates the position of HIF-2α in tumor initiation, improvement, and aggressiveness. Sinan is initially from Turkey, and did his PhD in Germany.
Perrine Burdeyron is a postdoc engaged on growing a mannequin to review neuroblastoma by utilizing human pluripotent stem cells with chick embryo as a bunch. This mannequin permits us to review totally different genes concerned on this childhood most cancers. Perrine is initially from France.
Tom Gregor is a postdoc engaged on the position of HIF-2α throughout neural crest stem cell-derived childhood most cancers development. Tom is initially from Czech Republic.
Marina Mazariegos is working as a lab engineer, and arrived to the lab six weeks in the past. She is concerned in a number of initiatives with totally different folks, in addition to basic administration and group of the lab. Marina is initially from Spain.
Niklas Engström is a lab engineer concerned in various initiatives, in addition to in sustaining the construction of the lab.
Elina Fredlund is a ultimate yr PhD candidate working to grasp the initiation of neuroblastoma with important deal with an early improvement protein that has an necessary position in embryogenesis and a suppressive perform in neuroblastoma.
Stina Andersson is a second yr PhD scholar, and her work focuses on how several types of neuroblastoma cells reply to numerous cues from the embryonic microenvironment.
Zana Stirn is a grasp scholar. She is working along with our postdoc Perrine on the mission to develop a human-chick chimera mannequin, that shall be used to govern totally different genes and pathways in neuroblastoma and consequently to get a greater perception into the event and origin of this most cancers. Zana is initially from Slovenia.
Pleun Jornick is a grasp scholar, fulfilling the final a part of her grasp internship right here. She research the mechanisms of a tumor-suppressor gene in neuroblastoma. Pleun is initially from The Netherlands.
Özgür Rubar Altin is a medical physician at first of his profession, and he’s doing an internship within the lab. He’s engaged on investigating the position of HIF-2α in rooster embryos and totally different tumor cells. Özgüris initially from Turkey.
Inés Sanz is a grasp scholar, investigating the position of how embryonic microenvironmental components have an effect on neuroblastoma cell habits. Inés is initially from Spain
Favorite method, and why?
Sofie Mohlin: There are such a lot of methods that we are able to use, every with its personal benefits and sweetness. However I’m going to go along with a ‘easy’ on: microinjections and electroporation in chick embryos. It’s such a fundamental method that’s been round for ages, but it’s the premise for thus many experiments and important information we’ve got on embryogenesis in the present day. Sadly, I don’t spend a whole lot of time on hands-on lab work anymore, however once I do it’s all the time by the microscope doing injections. Whereas it in a technique requires focus and focus, I have a tendency to enter a meditative state the place I can let go of stress and simply take pleasure in the great thing about the embryos, one after one after one…
Other than your individual analysis, what are you most enthusiastic about in developmental and stem cell biology?
Sofie Mohlin: I feel the method of (neural crest) stem cell lineage dedication is so delicate and thrilling. With the latest in-depth sequencing methods, we’ve come a good distance in understanding the genetics behind, and because of, lineage dedication. Nonetheless, there’s a lot left to grasp concerning the biology surrounding lineage dedication.
How do you method managing your group and all of the totally different duties required in your job?
Sofie Mohlin: My philosophy is that individuals are given full independence, however it comes with accountability. Within the lab we drive the initiatives ahead collectively, however every particular person mission is one particular person’s pet mission (or, somebody’s child, which is my favourite manner of expressing it). Nonetheless, I be certain I’m all the time accessible, as typically as potential bodily within the lab, in any other case being fast in answering questions through e mail/chat features. We even have time-fixed common lab conferences and one-on-one conferences with PhD college students. Planning and prioritization are key, however to be sincere it’s not all the time simple. With deadlines, grant purposes and tutorial commitments, I typically really feel that point for precise science is sparse. I attempt to be open to the group when very intense durations happen in order that they know why I is perhaps extra harassed and fewer accessible for a (hopefully quick) whereas. I’m additionally engaged on with the ability to say no to issues. There are such a lot of issues to do, and plenty of of those are enjoyable duties. But additionally, with a restricted variety of hours per day, with the ability to prioritize and say no is essential. On the finish of the day, the time once I’m the happiest at work is after conferences with lab members, the place we’ve got mentioned cool new knowledge, experiments, and future plans, leaving with the sensation of exhilaration. That is an exercise that I’d by no means skip!
What’s the smartest thing about the place you’re employed?
Sofie Mohlin: My group in fact! I actually take pleasure in discussing and doing science, in addition to chatting about on a regular basis life, with everybody, be it within the hall, within the lab, in one-on-one conferences or lab conferences. I additionally work shut with different nice PIs, offering me with a incredible peer neighborhood and surrounding.
Sinan Karakaya: One of the best a part of working in our analysis lab is the collaborative atmosphere fostered by our numerous group. Every member brings distinctive views and experience, creating an environment conducive to modern considering and problem-solving. Moreover, the supportive and inspiring nature of Sofie and colleagues nurture skilled development and fosters a way of camaraderie, making it an enriching and fulfilling expertise to be a part of our analysis endeavors.
Perrine Burdeyron: One of the best factor is the constructive atmosphere within the lab.
Marina Mazariegos: Undoubtedly the work atmosphere created by nice folks working for the nice of the entire lab and never for themselves. And in addition, the prospect of reaching targets to contribute to progress in medical analysis.
Elina Fredlund: One of the best issues are my colleagues and the plentiful alternatives accessible. Steering is quickly accessible upon request, as individuals are very pleasant and supportive.
Stina Andersson: I like studying new issues each day, and I actually respect the collaborative ambiance in our analysis group.
Zana Stirn: The atmosphere! I actually benefit from the dynamic of the group. We’ve many get togethers, workshops, potlucks, fikas. All of this contributes to a tremendous atmosphere, which makes coming to work much more pleasant.
Pleun Jornick: The ambiance within the lab is wonderful. It feels you possibly can all the time go to anybody with questions and that your opinion is actually appreciated. This makes me actually motivated to provide my all.
Özgür Rubar Altin: Wonderful colleagues and scientific working atmosphere.
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What’s there to do outdoors of the lab?
Sofie Mohlin: Lund is a really picturesque metropolis with numerous lovely previous buildings and environment, so simply strolling round city is sweet. Ten minutes on the prepare then takes you to Malmö, a beautiful metropolis with numerous tradition, sightseeing, parks, meals, and wine bars!
Sinan Karakaya: Outdoors of the lab, there are many alternatives to spend your time indoors or open air. Apart from being a scenic, historic city, Lund additionally provides number of indoor and out of doors actions together with museums, sports activities halls and trails for trekking and biking.
Perrine Burdeyron: In the course of the winter you possibly can take pleasure in ice skating and snow actions and through the summer season you possibly can benefit from the lengthy days to go for mountaineering and go to all of the nationwide parks within the south. Should you want the town, we’re near Copenhagen, the Danish capital.
Marina Mazariegos: It´s a small metropolis however yow will discover a whole lot of actions and there´re a whole lot of good locations to go to chill out with mates.
Elina Fredlund: Crossing the bridge, Copenhagen is only a 40 min prepare trip away. Söderåsen is a wonderful nationwide forest that’s value a go to throughout any season.
Stina Andersson: I take pleasure in spending my free time in nature or at dinner with family and friends.
Zana Stirn: Lund is sort of a huge scholar campus, so the scholar life may be very a lot alive. You’ll be able to take pleasure in totally different cafes, bars, parks and a wonderful botanical backyard. On the weekend, you can also make a visit to Lomma seashore or one in every of many pure parks within the space. For some larger metropolis vibes, Malmö and Copenhagen are solely a brief prepare trip away.
Pleun Jornick: As a world scholar in Sweden there’s a lot to find, however the custom I cherish essentially the most right here is “fika”. A espresso break with a candy pastry just a few instances every week is a celebration. There are a whole lot of totally different good cafés in Lund, so the problem is to attempt all of them.
Özgür Rubar Altin: Lund has unimaginable nature you can discover by bike. There’s a good soccer stadium the place you possibly can go to observe Lunds BK.